nephroprotective effects of feijoa sellowiana leaves extract on renal injury induced by acute dose of ecstasy (mdma) in mice

نویسندگان

mohammad karami department of toxicopharmacology, school of pharmacy, mazandaran university of medical sciences, sari, iran

faezeh karimian nokabadi department of toxicopharmacology, school of pharmacy, mazandaran university of medical sciences, sari, iran

mohammad ali ebrahimzadeh department of chemistry, school of pharmacy, mazandaran university of medical sciences, sari, iran

farshad naghshvar department of pathology, school of medicine, mazandaran university of medical sciences, sari, iran

چکیده

objective(s): because of the high total phenolic contents of feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (mdma) treated mice.   materials and methods: animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of f. sellowiana leaves, intra-peritoneally. after one hour, an acute administration of mdma (20 mg/kg, ip) was injected. nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. histopathological study was also used.   results   : both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (p <0.05). not statistically significant was observed in effect of two extracts (p>0.05). a decrease in urea/ creatinine ratio was observed following aqueous extract treatment. methanolic extract showed higher activity in increasing kidney glutathione (p conclusion:   f. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of mdma in mice.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice

  Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.   Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP)...

متن کامل

Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice

OBJECTIVE(S) Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. MATERIALS AND METHODS Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was inject...

متن کامل

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

The Hepatoprotective Effects of Corn Silk against Dose-induced Injury of Ecstasy (MDMA) Using Isolated Rat Liver Perfusion System

Background: Corn silk (CS) is widely used in Iranian traditional medicine. The aim of this study was to investigate hepatoprotective activity of CS by Isolated Rat Liver Perfusion System (IRLP). Methods: Hydro-alcoholic extract of corn silk (10, 20, 40, and 100 mg kg-1) was evaluated for its hepatoprotective activity by IRLP. Phenol and flavonoid contents of the extract were determined as gal...

متن کامل

Study of the Hepatoprotective Activity of Methanolic Extract of Feijoa sellowiana Fruits Against MDMA using the Isolated Rat Liver Perfusion System

liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants. Feijoa sellowiana (Myrtaceae) is an evergreen bush native to southern areas of South America, as well as Iran where the fruits are very popular. Feijoa has shown a potent antimicrobial effect. Morever, the antioxidant activity of total Feijoa extract has also been reported. MDMA or ecstasy is a ...

متن کامل

Study of the Hepatoprotective Activity of Methanolic Extract of Feijoa sellowiana Fruits Against MDMA using the Isolated Rat Liver Perfusion System

liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants. Feijoa sellowiana (Myrtaceae) is an evergreen bush native to southern areas of South America, as well as Iran where the fruits are very popular. Feijoa has shown a potent antimicrobial effect. Morever, the antioxidant activity of total Feijoa extract has also been reported. MDMA or ecstasy is a ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۷، شماره ۱، صفحات ۶۹-۷۲

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023